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Fentanyl Pills (also known as fentanil) is a potent, synthetic opioid pain medication with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Fentanyl is 50 and 100 times potent than morphine.
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Paul Janssen made the pills in 1960, following the medical inception of pethidine several years earlier. Janssen developed fentanyl by assaying analogues of the structurally related drug pethidine for opioid activity. The widespread use of fentanyl triggered the production of fentanyl citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry), which entered medical use as a general anaesthetic under the trade name Sublimaze in the 1960s.
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Fentanyl Pills In the mid-1990s, fentanyl was introduced for palliative use with the fentanyl patch, followed in the next decade by the introduction of the fentanyl lollipop, dissolving tablets, and sublingual spray which is resorbed through the skin inside the mouth. As of 2012 fentanyl was the most widely used synthetic opioid in medicine. In 2013, 1700 kilograms were used globally.
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Also, the use of fentanyl has led to thousands of overdose deaths. Deaths have also resulted from improper medical use. Fentanyl has a relatively wide therapeutic index (270) which makes it a very safe surgical anaesthetic when monitored carefully; however, its extreme potency requires careful measurements of highly diluted fentanyl in solution; attempting to accurately measure a dose of pure fentanyl powder is impractical.
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